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Lymphatic Filariasis

1. A typical presentation of Lymphatic Filariasis (Filaria Nodule)

1. Atypical Lymphatic nodules found in 7.6% of population in endemic areas of bancroftian filariasis in Orissa [Acta tropica 55(1993),53-60]

2. Death of adult worm leads to formation of granulomatous nodules.

3. Histopathological section of nodule demonstrate granuloma formation and adult parasites IJMR, 84, Sept 1986, 270-274.

4. Acknowledge the experience, expertise and capabilities and give due importance in collaboration, resource sharing and partnership.

2. Sub Clinical Lymphatic Pathology in Filaria (W. bancrofti) infected children: Linking infection to disease

3. MDA has potential to revert the pathology; Hence preventing morbidity

A case of 12 Yrs Male, Asymptomatic child with Lymphatic flow obstruction on left leg at Baseline shown Complete reversal at 1 Year & sustained at 18 Months with single annual dose of DEC (6 mg/ Kg) + Albendazole (400 mg)

4. Maternal filarial infection is a risk factor for neonates

MDA program for elimination of filariasis is going on exempting pregnant mother and children age below 2 years. Our study shows that Transplacental transfer filarial antigen and elevated levels of IgG4 (Marker of filarial infection) may make the neonates more susceptible to filariasis. So MDA program for control of filariasis should target women of child bearing age

5. XID mice : A New model for filariasis

CBA/N mice infected with B. malayi infective larvae(L3 )developed into juvenile adults between 45-50 days post infection. This has offered a model to study development of immunity in filariasis

6. PROTECTIVE POTENTIALITY OF A NOVEL FILARIAL ANTIGEN IN LYMPHATIC FILARIASIS

7. UNIFORM LOW DOSE DEC ( 100MG) TO ALL AGE GROUPS : POTENTIAL FOR IMPROVING MDA COMPLIANCE IN NATIONAL PROGRAMME
Ivermectin- oral application in treatment of Scabies : First documentation